Access to oxoquinoline heterocycles by N-heterocyclic carbene catalyzed ester activation for selective reaction with an enone.
نویسندگان
چکیده
Organocatalytic ester activation is developed for a highly selective cascade reaction between saturated esters and amino enones. The reaction involves activation of the β-carbon atom of the ester as a key step. This method allows a single-step access to multicyclic oxoquinoline-type heterocycles with high enantiomeric ratios.
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 53 25 شماره
صفحات -
تاریخ انتشار 2014